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The Impact of BCL6 Expression on Cancer Cell Behaviour in a Glioma Model

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posted on 2025-01-29, 01:51 authored by Naychi Myo Min

Glioblastoma (GBM) is the most aggressive and malignant brain tumour, exhibiting some of the lowest survival rates among various cancers, even following interventions such as surgical resection, chemotherapy, and radiation therapy. GBM is characterised by its heterogeneity, invasive phenotype, and resistance to conventional treatment modalities. Key drivers of tumorigenesis play crucial roles in facilitating the ‘hallmarks’ of cancer, including uncontrolled proliferation, evasion of growth-regulatory mechanisms, and, critically, resistance to therapeutic interventions. A comprehensive understanding of these genetic drivers is essential for the development of innovative therapeutic strategies aimed at improving patient outcomes.

BCL6, an established oncogenic driver in diffuse large B-cell lymphomas, also plays a significant role in solid tumours by repressing tumour suppressor genes and promoting survival under stress conditions. Preliminary studies indicate that the inhibition of BCL6 in certain tumour models, including GBM, correlates with reduced tumour growth and increased sensitivity to standard therapies.

In this study, I utilized a newly developed genetically engineered mouse cell line model to investigate the role of BCL6 in GBM. The findings demonstrated that BCL6 overexpression significantly enhanced the proliferation rate of transfected GBM cells without affecting their migratory capacity. Furthermore, the data suggested that BCL6 expression contributes to improved survival rates following chemotherapy exposure. These results substantiate the hypothesis that BCL6 functions as a pivotal driver in the pathophysiology of GBM, positioning it as a promising target for therapeutic intervention. Future investigations will focus on determining whether these BCL6-overexpressing cell lines can initiate tumorigenesis and exploring the potential of BCL6 inhibitors as targeted therapeutic agents.

History

Copyright Date

2025-01-29

Date of Award

2025-01-29

Publisher

Te Herenga Waka—Victoria University of Wellington

Rights License

CC BY-NC-SA 4.0

Degree Discipline

Biomedical Science; Cell and Molecular Bioscience

Degree Grantor

Te Herenga Waka—Victoria University of Wellington

Degree Level

Masters

Degree Name

Master of Biomedical Science

ANZSRC Type Of Activity code

4 Experimental research

Victoria University of Wellington Item Type

Awarded Research Masters Thesis

Language

en_NZ

Victoria University of Wellington School

School of Biological Sciences

Advisors

McConnell, Melanie