20 Ameratunga NZMJ ACE2 decoy.pdf (501.9 kB)
Inhaled modified angiotensin converting enzyme 2 (ACE2) as a decoy to mitigate SARS-CoV-2 infection
journal contributionposted on 2022-08-04, 22:21 authored by R Ameratunga, K Lehnert, E Leung, Davide ComolettiDavide Comoletti, R Snell, ST Woon, W Abbott, E Mears, R Steele, J McKee, A Muscroff-Taylor, S Ameratunga, N Medlicott, S Das, W Rolleston, ME Quinones-Mateu, H Petousis-Harris, A Jordan
COVID-19 is a new zoonotic disease caused by the SARS-CoV-2 virus. Since its emergence in Wuhan City, China, the virus has rapidly spread across the globe causing calamitous health, economic and societal consequences. It causes disproportionately severe disease in the elderly and those with co-morbidities, such as hypertension and diabetes. There is currently no proven treatment for COVID-19 and a safe and effective vaccine is at least a year away. The virus gains access to the respiratory epithelium through cell surface angiotensin converting enzyme 2 (ACE2). The receptor binding domain (RBD) of the virus is unlikely to mutate without loss of pathogenicity and thus represents an attractive target for antiviral treatment. Inhaled modified recombinant human ACE2, may bind SARS-CoV-2 and mitigate lung damage. This decoy strategy is unlikely to provoke an adverse immune response and may reduce morbidity and mortality in high-risk groups.
Preferred citationAmeratunga, R., Lehnert, K., Leung, E., Comoletti, D., Snell, R., Woon, S. T., Abbott, W., Mears, E., Steele, R., McKee, J., Muscroff-Taylor, A., Ameratunga, S., Medlicott, N., Das, S., Rolleston, W., Quinones-Mateu, M. E., Petousis-Harris, H. & Jordan, A. (2020). Inhaled modified angiotensin converting enzyme 2 (ACE2) as a decoy to mitigate SARS-CoV-2 infection. New Zealand Medical Journal, 133(1515), 112-118. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000592128200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=fce46881ccd595a90ef171eda32e42ef
Journal titleNew Zealand Medical Journal
CategoriesNo categories selected
Administration, InhalationAngiotensin-Converting Enzyme 2BetacoronavirusCOVID-19Coronavirus InfectionsHumansLungPandemicsPeptidyl-Dipeptidase APneumonia, ViralProtein BindingRecombinant ProteinsSARS-CoV-2Spike Glycoprotein, CoronavirusBiodefensePreventionClinical ResearchClinical Trials and Supportive ActivitiesInfectious DiseasesImmunizationVaccine Related5 Development of treatments and therapeutic interventions5.1 PharmaceuticalsInfection3 Good Health and Well BeingMedical and Health SciencesGeneral & Internal Medicine