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Hamigeran G Does Not Affect Golgi Structure or Function in HEK293 Cells

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posted on 2022-11-29, 00:19 authored by Ameet SinghAmeet Singh, Catrina Olivera, Euan R Russell, John MillerJohn Miller, Peter NorthcotePeter Northcote
The hamigerans are diterpenoid secondary metabolites isolated from the New Zealand marine sponge Hamigera tarangaensis. Of all the hamigerans that have been isolated and characterised at Victoria University of Wellington, hamigeran G showed the most potent anti-proliferative activity against a mammalian cancer cell line. We previously reported that it might be targeting the Golgi network of cells based on a chemical genomic screen on yeast (Saccharomyces cerevisiae). Here, we investigated the effects of hamigeran G on the Golgi network of mammalian cells and showed that it did not have a significant effect on Golgi apparatus morphology or Golgi network functions such as protein secretion and endocytosis. Results of this study, therefore, conclude that the Golgi network is unlikely to be the primary target of hamigeran G's anti-proliferative activity. Further work is needed to fully elucidate the mechanism of action and target(s) of hamigeran G.

History

Preferred citation

Singh, A. J., Olivera, C., Russell, E. R., Miller, J. H. & Northcote, P. T. (2019). Hamigeran G Does Not Affect Golgi Structure or Function in HEK293 Cells. Drug and Drug Abuse, 1-5. https://doi.org/10.31487/j.dda.2019.01.03

Journal title

Drug and Drug Abuse

Publication date

2019-08-19

Pagination

1-5

Publisher

Science Repository OU

Publication status

Published

Online publication date

2019-08-19

ISSN

2674-5062

Language

en

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