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Costatone C—A new halogenated monoterpene from the New Zealand red alga plocamium angustum

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posted on 18.06.2020 by Joe Bracegirdle, Z Sohail, Michael Fairhurst, Monica Gerth, Giuseppe Zuccarello, M Ali Hashmi, Robert Keyzers
© 2019 by the authors Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the planar structure of 7 was achieved through conventional NMR and (−)-HR-APCI-MS techniques, and the absolute configuration by comparison of experimental and DFT-calculated ECD spectra. The absolute configuration of 8 was determined using Mosher’s method. Compound 7 showed mild antibacterial activity against Staphylococcus aureus and S. epidermidis. The state of Plocamium taxonomy and its implications upon natural product distributions, especially across samples from specimens collected in different countries, is also discussed.

History

Preferred citation

Bracegirdle, J., Sohail, Z., Fairhurst, M.J., Gerth, M.L., Zuccarello, G.C., Ali Hashmi, M. & Keyzers, R.A. (2019). Costatone C—A new halogenated monoterpene from the New Zealand red alga plocamium angustum. Marine Drugs, 17(7), 418-418. https://doi.org/10.3390/md17070418

Journal title

Marine Drugs

Volume

17

Issue

7

Publication date

19/07/2019

Pagination

418-418

Publisher

MDPI AG

Publication status

Published

Online publication date

19/07/2019

ISSN

1660-3397

eISSN

1660-3397

Article number

ARTN 418

Language

en

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